A nasal omicron vaccine booster elicits potent neutralizing antibody response against emerging SARS-CoV-2 variants비강 오미크론 백신 부스터는 새로운 SARS-CoV-2 변이체에 대한 강력한 중화 항체 반응을 이끌어냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] absence adjuvants administration antibody Antibody Response boost booster Bronchoalveolar lavage caused clinical trial composed COVID-19 COVID-19 pandemic current deaths delta variant described disease severity domain dose effective Elevation elicit evidenced FIVE fused human infection human infections humans IgA Immunity immunogen intranasal leads mice MOST mucosal nasal nasal protein vaccine booster Neutralizing activity neutralizing antibody Neutralizing antibody response omicron Omicron variant omicron variant. Protein Receptor binding domain reduce respiratory SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS-CoV-2 spike SARS-CoV-2 transmission SARS-CoV-2 variant severity significantly single dose suggested the antibody response the disease vaccination Vaccine virus infection wild-type [DOI] 10.1080/22221751.2022.2053365 PMC 바로가기 [Article Type] Article
Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
COVID-19 intranasal vaccines: current progress, advantages, prospects, and challengesCOVID-19 비강내 백신: 현재 진행 상황, 이점, 전망 및 과제Review Published on 2022-11-302022-09-12 Journal: Human vaccines & immunotherapeutics [Category] MERS, SARS, 진단, [키워드] added Administered administration Antibody Response Cell-mediated immunity cellular immunity country COVID-19 COVID-19 pandemic COVID-19 vaccine disease highlight immune response Immunity induce injected injection intramuscular intranasal intranasal vaccine limit MOST mucosal mucosal immunity. Multiple nasal pandemic Prevent Protective Replication robust SARS-CoV-2 SARS-CoV-2 vaccine secretory IgA shown stimulate Vaccine Vaccines virus infection virus transmission [DOI] 10.1080/21645515.2022.2045853 PMC 바로가기 [Article Type] Review
Multiplex Hybrid Antigen-Capture LC-MRM Quantification in Sera and Nasal Lining Fluid of AZD7442, a SARS-CoV-2-Targeting Antibody CombinationArticle Published on 2022-11-012022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] antibodies antibody applicability approach binding capture reagent clinical analysis Combination complementarity-determining region conditions coronavirus disease Critical demonstrated domain extension Final hybrid implementation Infection Ligand limit lining mAb macromolecules Magnetic beads matrix effect monoclonal antibody multidimensional nasal offer patient population peptide performed platform quantification reagent reagents reproducibility required sensitivity serum significantly Tandem mass spectrometry Treatment vaccination viral spike protein [DOI] 10.1021/acs.analchem.2c01320 PMC 바로가기
A triple-RBD-based mucosal vaccine provides broad protection against SARS-CoV-2 variants of concernArticle Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibodies antigenic chimeric correlated Delta effective elicit flagellin Flagellin adjuvant human ACE2 IgA immunization Infection initial intranasal intranasal immunization Lower lung mucosal mucosal vaccine Mutation nasal neutralizing antibody neutralizing immunity omicron pathology Protein provide RBD reduce SARS-CoV-2 SARS-CoV-2 variant secretory IgA significantly specificity Spread tissue pathology transgenic mice transmission potential Triple-RBD Vaccine vaccine candidate variant Variant of concern. Viral RNA [DOI] 10.1038/s41423-022-00929-3 PMC 바로가기
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccineArticle Published on 2022-11-012022-11-15 Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] activated airway epithelial cells Antigen B cell Beta Cell cross-reactive delta variant dendritic cell development domain effective elicited facilitated humoral IgA response immune response Immunity induce Inflammation intranasal long-lasting lung mice Microparticle mucosal nasal Parenteral porous prime and boost Protective RBD SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 vaccine subunit type 1 helper vaccination Vaccinations Vaccine variant Viral load [DOI] 10.1016/j.trsl.2022.06.004 PMC 바로가기
Diagnostic accuracy of a novel SARS CoV-2 rapid antigen test and usefulness of specimens collected from the anterior nasal cavityArticle Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] Accuracy Ag-RDT age Antigen collected criteria cycle threshold Cycle threshold value diagnostic Diagnostic accuracy enrolled Hospitalization meet moderate nasal nasal mucosa nasopharyngeal Patient polymerase chain primary end point provide Rapid diagnostic test real-time polymerase chain reaction remained SARS CoV-2 SARS-CoV-2 sensitivity Sensitivity and specificity specificity specimen specimens utility Viral load Viral load. World Health Organization [DOI] 10.1016/j.ijid.2022.09.018 PMC 바로가기
Mid-term pulmonary sequelae after hospitalisation for COVID-19: The French SISCOVID cohortResearch article Published on 2022-11-012022-10-05 Journal: Respiratory medicine and research [Category] 임상, [키워드] age Chest computed tomography clinical examination Clinical features Cohort complications consequence COVID-19 CT-scan described diffusing discharge Dyspnoea evaluated Follow-up French functional hospital discharge hospitalisation hospitalised ICU impairment Improved independent risk factor intensive care Invasive mechanical ventilation lung lung capacity Lung function mMRC multicentre nasal non-invasive ventilation observational study outcome Pathogenesis Patient Patient discharge Pneumonia Pulmonary function tests radiological Result sequelae severe COVID-19 significantly more therapeutic option ventilatory [DOI] 10.1016/j.resmer.2022.100933 [Article Type] Research article
Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airwaysArticle Published on 2022-10-282022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 airway airway epithelium airways association C15orf48 cell population changes in characterized club co-expressed cohorts CTSL diagnostic workup disease severity elevated epithelial cells expressed expressing expression expression data Gene Expression gene expression pattern Goblet cell increase in indicated individual Infection lung cancer lung cancer risk modulate modulated nasal Population SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection scRNA-seq secretory cell severe disease significantly similarity smoker smoking smoking status subpopulation TMPRSS2 viral entry Viral load [DOI] 10.1038/s41598-022-17832-6 PMC 바로가기
Longitudinal serologic and viral testing post-SARS-CoV-2 infection and post-receipt of mRNA COVID-19 vaccine in a nursing home cohort-Georgia, October 2020‒April 2021Article Published on 2022-10-272022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] administration Antibody detection Antibody Response binding binding antibody blood collection Card Cohort conducted COVID-19 COVID-19 vaccination COVID-19 vaccine Culture detectable dose evaluate evaluated Final first dose geometric IgA antibodies IgA antibody IgG IgG titer IgM antibodies immune response Immunocompromised Infection longitudinal median age mounted mRNA nasal nine nursing home observation participant polymerase chain positive Post-infection Quantitative questionnaire reverse transcription robust RT-PCR SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2-specific immune response serology specimen subsequent vaccination viral culture [DOI] 10.1371/journal.pone.0275718 PMC 바로가기